陈国勋 博士 教授 博士生导师
陈国勋博士于1982年进入武汉大学病毒及分子生物学系求学。并于1986年取得本科学士和1989年取得硕士研究生学位。1989至1995于湖北省医学科学院从事研究工作。1995年来美，2001年于德克萨斯州立大学西南医学学中心（达拉斯）取得生物化学和分子生物学哲学博士学位。同年进入西南医学中心诺贝尔奖得主Joseph Goldstein和Michael Brown博士实验室从事博士后研究。2006年起至2022年底作为终身教授任职于美国田纳西营养系。一直从事着本科及研究生的教学及管理工作。目前是美国心脏病学会，糖尿病学分和营养学会会员。同时也是北美华人营养学会和北美华人糖尿病学分终身会员。于2009年获得美国心脏病学会美国心脏病学会营养，代谢和运动分会新科学家奖。来美27年的时间里，一直从事着与慢性代谢性疾病分子机制的研究。曾任美国糖尿病学会营养科学和代谢分会主席（2020-2022）和卸任主席（2022-2024）。曾任北美华人营养学会主席（2019-2020）和卸任主席（2020-2021）。现任美国营养学会（American Society for Nutrition)财务及审计委员会委员（2021-2024）。现任The Open Journal of Biotechnology 主编（Bentham Science Publishers)。任Frontier Pharmacology in Gastrointestinal and Hepatic Pharmacology, Food Science and Human Wellness, Journal of Future Foods, 和 Global Health Research and Policy等杂志的副主编。
教育经历
2001/07至2006/07 美国德州大学西南医学中心，分子遗传学系，博士后
1997/08至2001/06 美国德州大学西南医学中心，生物化学及分子生物学系，博士
1986/09至1989/07 武汉大学，病毒及分子生物学系，硕士
1982/09至1986/07 武汉大学，病毒及分子生物学系，学士
工作经历
2023/01至今 AG真人国际食品科技学院，AG真人国际 教授
2006/08至2022/12 美国田纳西大学诺克斯维尔分校，营养学系，tenure-track 助理教授, tenured副教授
1995/03至1997/07 美国德州大学西南医学中心, 访问学者/研究助理
1987/07至1995/02 湖北省医学科学院病毒所，助理研究员
研究领域
My long-term research interest is to understand the biochemical and molecular mechanisms of metabolic changes associated with metabolic diseases, such as obesity and type 2 diabetes，and find ways to prevent the development of these diseases through food and nutrition. In the future, we would like to develop precision/personalized intervention methods to prevent and treat diseases related to malnutrition and overnutrition.
代表成果
【科研与教学奖励】
1. 2020: Jacquelyn Orlando DeJonge Faculty Award, College of Education Health and Human Science, the University of Tennessee, Knoxville
2. 2016: Service Excellence and Leadership Award, the University of Tennessee, Knoxville
3. 2009: NPAM Young Investigator Award at American Heart Association’s Scientific Sessions 2009, Orlando, Florida
4. 1999-2001: Research Trainee, NIH training grant award, UT Southwestern Medical Center at Dallas
5. 1999: Sigma-Xi, University of Texas Southwestern Medical Center at Dallas
6. 1998: Outstanding Scientific Poster, Graduate Student Organization Poster Session, University of Texas Southwestern Medical Center at Dallas
7. 1987, 1988: Excellent Graduate Student of Wuhan University, Wuhan, China
【代表性论文】
1. Chen G. Assaying of TGFs Produced by MA782/5s-8101 Mouse Mammary Tumor Cell Line. (1988) The Postgraduate Journal of Wuhan University. 1:93-95.
2. Chen, G. and Li, W.X., (1989) Studies of Cell Growth Stimulating Factors in Malignant Lung Adenocarcinoma Pleural Effusions. The Cancer Research on Prevention and Treatment, 16:200-202.
3. Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O’Doherty, R., Newgard, C.B., and Unger, R.H., (1996) Disappearance of Body Fat in Normal Rats Induced by Adenovirus-Mediated Leptin Gene Therapy. Proceedings of the National Academy of Sciences USA 93:14795-14799. DOI: 10.1073/pnas.93.25.14795
4. Chen, G., Hohmeier, H., Gasa, R., Tran, V., and Newgard, C.B. (2000) Selection of Insulinoma Cell Lines With Resistance to IL-1ß and IFN--Induced Cytotoxicity. Diabetes: 49:562-570. DOI: 10.2337/diabetes.49.3.424
5. Chen, G., Hohmeier, H., and Newgard, C.B. (2001) Expression of the Transcription Factor STAT-1 in Insulinoma Cells Protects Against Cytotoxic Effects of Multiple Cytokines. The Journal of Biological Chemistry 276: 766-772.
6. Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Kahn, C.R., Granner, D.K., Newgard, C.B., and Spiegelman, B.M.. (2001) Control of Hepatic Gluconeogenesis Through the Transcriptional Coactivator PGC-1. Nature: 413:131-138.
7. Chen, G., Liang G., Ou J., Goldstein, J.L., and Brown, M.S. (2004) Central Role for Liver X Receptor in Insulin-Mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Proceedings of the National Academy of Sciences USA 101: 11245-11250. DOI: 10.1073/pnas.0404297101
8. Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.L., and Russell, D.W. (2007) Enzymatic Reduction of Oxysterols Impairs LXR Signaling in Cultured Cells and the Livers of Mice. Cell Metabolism. 5:73-9
9. Chen, G. (2007) Liver Lipid Molecules Induce PEPCK-C Gene Transcription and Attenuate Insulin Action. Biochemical and Biophysical Research Communications. 361(3):805-10.
10. Chen, G., Zhang, Y., Lu, D., Li, N., and Ross, A.C. (2009) Retinoids Synergize with Insulin to Induce Hepatic Gck Expression. Biochemical Journal. 419(3):645-54.
11. Li, R., Chen, W., Li, Y., Zhang, Y., and Chen, G. (2011) Retinoids Synergized with Insulin to Induce Srebp-1c Expression and Activated Its Promoter via the Two Liver X Receptor Binding Sites That Mediate Insulin Action. Biochemical and Biophysical Research Communications. 406(2):268-72
12. Zhang, Y., Li, R., Chen, W., Li, Y., and Chen, G. (2011) Retinoids Induced Pck1 Expression and Attenuated Insulin-mediated Suppression of Its Expression via Activation of Retinoic Acid Receptor in Primary Rat Hepatocytes. Molecular and Cellular Biochemistry. 355(1):1-8.
13. Zhang, Y., Li, R., Chen, W., Li, Y., Ge, Y., and Chen, G. (2011) Insulin-Regulated Srebp-1c and Pck1 mRNA Expression in Primary Hepatocytes from Zucker Fatty But Not Lean Rats is Affected by Feeding Conditions. PLoS One 6(6):e21342
14. Zhao, S., Li, R., Li, Y., Chen, W., Zhang, Y., and Chen, G. (2012) Roles of Vitamin A Status and Retinoids in Glucose and Fatty Acid Metabolism. Biochemistry and Cell Biology. 90(2): 142-152
15. Zhang, Y., Li, R., Li, Y., Chen, W., Zhao, S., and Chen, G. (2012) Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats. Biochemistry and Cell Biology. 90(4):548-57
16. Howell, M. and Chen, G. (2012) Is There A Role of Vitamin A in Hepatic Glucose and Fatty Acid Metabolism? Journal of Nutrition & Food Sciences. 2:e111
17. Li, Y., Zhang, Y., Li, R., Chen, W., Howell, M., Zhang, R., and Chen, G. (2012) The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells. PLoS One. 7(9):e45210
18. Chen, G. and Pang, Z. (2013) Endocannabinoids and Obesity. Vitamins and Hormones. 91:325-68.
19. Chen, G. (2013) Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance. ISRN Hepatology. Article ID 534972. dx.doi.org/10.1155/2013/534972
20. Guan, H. and Chen, G. (2014) Factors Affecting Insulin-Regulated Hepatic Gene Expression. Progress in Molecular Biology and Translational Science. 121:165-215
21. Howell, M., Li, R., Zhang, R., Li, Y., Chen, W., and Chen, G. (2014) The expression of Apoc3 mRNA is regulated by HNF4α and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells. Molecular and Cellular Biochemistry. 387:241-250
22. Chen, W., and Chen, G., (2014) The roles of vitamin A in the regulation of carbohydrate, lipid and protein metabolism. Journal of Clinical Medicine, 3(2), 453-479
23. Li, R., Zhang, R., Li, Y., Zhu B., Chen, W., Zhang, Y., and Chen, G. (2014) A retinoic acid responsive element in the hepatic Gck promoter interacts with RARα, HNF4α, COUP-TFII, which affect the retinoic acid- and insulin-mediated Gck expression. J Nutr Biochem, 25(9):964-76
24. Chen, W., Howell, M., Li, Y., Li, R., and Chen, G. (2014) Vitamin A and feeding statuses modulate the insulin-regulated gene expression in primary rat hepatocytes. PLoS One, 9(8):e100868.
25. Chen, W, Goff, MR, Kuang, H, Chen, G. (2015) Higher Protein Kinase C ζ in Fatty Rat Liver and Its Effect on Insulin Actions in Primary Hepatocytes. PLoS One. 10(3):e0121890. doi: 10.1371/journal.pone.0121890. eCollection 2015. PubMed PMID: 25822413; PubMed Central PMCID: PMC4379029.
26. Chen, G. (2015) The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease. Curr Drug Targets. 16(12):1281-92, PubMed PMID: 25808650.
27. Li, Y., Li, R., Chen, W., and Chen, G. (2016) Vitamin A status and its metabolism contribute to the regulation of hepatic genes during the cycle of fasting and refeeding in rats. J Nutr Biochem. 30(4):33-43. doi:10.1016/j.jnutbio.2015.11.012
28. Huang, XJ., Li, J., Mei, ZY., Chen, G. (2016) Gentiopicroside and sweroside from Veratrilla baillonii Franch induced phosphorylation of Akt and suppressed Pck1 expression in hepatoma cells. Biochemistry and Cell Biology. 94(3):270-8. doi: 10.1139/bcb-2015-0173
29. Li, Y., Liu, Y. and Chen, G. (2017) Vitamin A status affects the plasma parameters and regulation of hepatic genes in streptozotocin-induced diabetic rats. Biochimie. 2017 Jun;137:1-11. doi: 10.1016/j.biochi.2017.02.012. Epub 2017 Feb 24.
30. Yang, F., and Chen, G. (2018) Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis. World Journal of Gastroenterology. 2018 Sep 28;24(36):4132-4151. doi: 10.3748/wjg.v24.i36.4132.
31. Kuang, H., Yang, F., Zhang, Y., Wang, T., and Chen, G. (2018) The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis. Cholesterol, Volume 2018, Article ID 6303810 (22 pages). https://doi.org/10.1155/2018/6303810.
32. Kuang, H., Wei, CH., Wang, T., Eastep, J., Li, Y., Chen, G. (2019) Vitamin A Status Affects Weight Gain and Hepatic Glucose Metabolism in Rats Fed a High-Fat Diet. Molecular and Cellular Biochemistry 2019 Feb; 25:1-9. https://doi.org/10.1139/bcb-2018-0284
33. Goff, M. and Chen G. (2020) Long-Term Treatment with Insulin and Retinoic Acid Increased Glucose Utilization in L6 Muscle Cells via Glycogenesis. Biochem Cell Biol. 2020 Dec;98(6):683-697. doi: 10.1139/bcb-2020-0131.
34. Zhang, Y., Wang, T., Hu, X., and Chen, G. (2020) Vitamin A and Diabetes. Journal of Medicinal Food. 24 Nov 2020, 24(8):775-785. doi: 10.1089/jmf.2020.0147
35. Chen, G. (2021) The Interactions of Insulin and Vitamin A Signaling Systems for the Regulation of Hepatic Glucose and Lipid Metabolism. Cells. 2021 Aug 21;10(8):2160. doi: 10.3390/cells10082160.
36. Wang, T, Tang, X., Hu, X., Wang, J., and Chen, G. (2022) Reduction in the Dietary VA Status Prevents Type 2 Diabetes and Obesity in Zucker Diabetic Fatty Rats. Biomolecules, 2022, 12(4), 528. doi.org/10.3390/biom12040528
37. Lu, V., Zhang, J., and Chen, G. (2022) Can Nutrition Interventions Tackle the Global Insulin Affordability via Improving Diabetes Management and Reducing Insulin Demand? Global Health Research and Policy, 2022, 7:13; doi.org/10.1186/s41256-022-00247-1
38. Chen, R. and Chen, G. (2022) Personalized nutrition for people with diabetes and at risk of diabetes has begun. Journal of Future Foods, 2022 Sept, 2(3):193-202. doi.org/10.1016/j.jfutfo.2022.06.001
【授权发明专利】
U.S. Patent Number: 6,171,856B1
Patent Title: Methods and Compositions Relating to NO-mediated Cytotoxicity.
科研项目
1. The University of Tennessee at Knoxville; Start-up Fund: The Effects of Hepatic Lipids on the Expression of Genes in Hepatocytes
2. Allen Foundation Inc; Research Grant: Determining the Role of Vitamin A Metabolism in Obesity Development
3. American Heart Association National Program; Scientist Development Grant: Determining the Mechanism by Which Retinoids Synergize with Insulin to Stimulate Hepatic Gck Expression
4. The Graduate School at the University of Tennessee at Knoxville; Professional Development Award: Role and Mechanism of RA-induced SREBP-1c Expression in Pancreatic Beta Cells
5. The Affymetrix Core Facility at the University of Tennessee at Knoxville: Determining the Effects of Vitamin A Status on the Expression of Genes in Rat Liver, Muscle and Fat Tissues
6. The Graduate School at the University of Tennessee at Knoxville; Professional Development Award: Determine the effects of the elevated retinaldehyde dehydrogenase 1 expression in hepatocytes from Zucker fatty rats on the cell responses to insulin and retinoids
7. The Metabolic Translational Research Initiative (MTRI) Organized Research Unit: Determining the effects of variable feeding frequency on the body weight gain and metabolism in Sprague-Dawley rats
8. Zestern Biotechnology Inc, Research Grant: Regulation of Raldh1 mRNA and protein levels in the liver of rats in the cycle of fasting and refeeding; 10/1/2015 – 9/30/2017 - $10,000 – Principal Investigator
9. Zestern Biotechnology Inc, Research Grant: Analysis of insulin-regulated glucose transporter 4 protein expression using a novel quantitative dot blot method and traditional western-blot
10. Diabetes Action Research and Education Foundation, research grant: Determine the role of vitamin A in the development of type 2 diabetes in Zucker diabetic fatty rats Anticipating $20,000.00 from Diabetes Action Research and Education Foundation
11. Diabetes Action Research and Education Foundation, research grant: The effects of Metformin and Berberine on the prevention and treatment of type 2 diabetes
12. Diabetes Action Research and Education Foundation, research grant: Determine the effects of statins on the development of type 2 diabetes and the underlying molecular mechanisms
联系邮箱
1097582422@qq.com
